How does the skin age?

Understanding “genetically programmed” aging

Professeur Roger Renou, Head of Sisley Laboratories

Day after day, skin is subjected to extrinsic aging, caused by outside aggressions, but also intrinsic (genetically programmed) aging, which is inscribed in the cell’s DNA.
When skin is young, the mother cells in the germinative layer have a natural capacity to repair themselves, perfectly counterbalancing their deterioration: they multiply into new, identical daughter cells.


With age, this natural self-repair process loses strength: errors and faults gradually accumulate.
The multiplication of mother cells into daughter cells slows down, and daughter cells ineluctably deteriorate.
The cells are damaged and aging becomes visible: wrinkles, loss of firmness, loss of radiance…